home
***
CD-ROM
|
disk
|
FTP
|
other
***
search
/
Shareware Overload Trio 2
/
Shareware Overload Trio Volume 2 (Chestnut CD-ROM).ISO
/
dir26
/
med9406d.zip
/
M9460742.TXT
< prev
next >
Wrap
Text File
|
1994-06-25
|
3KB
|
45 lines
Document 0742
DOCN M9460742
TI Epstein-Barr virus latent and replicative gene expression in
post-transplant lymphoproliferative disorders and AIDS-related
non-Hodgkin's lymphomas.French Study Group of Pathology for
HIV-associated Tumors.
DT 9408
AU Rea D; Delecluse HJ; Hamilton-Dutoit SJ; Marelle L; Joab I; Edelman L;
Finet JF; Raphael M; Departement d'Hematologie, Hopital
Pitie-Salpetriere, Paris,; France.
SO Ann Oncol. 1994;5 Suppl 1:S113-6. Unique Identifier : AIDSLINE
MED/94226932
AB In acquired immunodeficiency, B-cell proliferation is usually associated
with Epstein-Barr virus (EBV), implying the impairment of the normal
control of EBV and EBV-infected cells. It has been assumed that EBV
infection is latent in lymphoproliferative disorders. In order to
determine the type of latency and to investigate whether any
lymphoproliferative disorders enter into the lytic cycle, we analyzed
the expression of latent and replicative EBV genes in 9 post-transplant
lymphoproliferative disorders (PTLD) and in 23 EBV-positive AIDS-related
non-Hodgkin's lymphomas (AR-NHL). The PTLD cases were categorized into
polyclonal or monoclonal polymorphic tumors and monoclonal monomorphic
tumors. The AR-NHL cases included large-cell/immunoblastic (LC/IB) and
Burkitt's lymphoma (BL) groups. We demonstrated that varying patterns of
latent-viral-gene expression are exhibited showing the 3 forms of
latency. Polymorphic PTLD and LC/IB AR-NHL frequently expressed type II
or III latency, whereas monomorphic tumors and BL AR-NHL showed type I
latency. It is noteworthy that 3 cases of BL AR-NHL expressed latency II
form. Induction of lytic cycle highlighted by the expression of BZLF1
occurred in 55.5% of PTLD, 36% of LC/IB and 22% of BL AR-NHL. In
contrast, late viral proteins indicating productive cycle were present
in 22% of PTLD, 14% of LC/IB, and were absent in BL cases. These data
suggest that the impairment of EBV control permits disruption of
latency, but the initiation of the lytic cycle may not always lead to
viral production.
DE Gene Expression Herpesvirus 4, Human/*GENETICS/PHYSIOLOGY Human
Lymphoma, AIDS-Related/*GENETICS Lymphoproliferative
Disorders/*GENETICS Organ Transplantation/*ADVERSE EFFECTS Support,
Non-U.S. Gov't Virus Latency/*GENETICS Virus Replication/*GENETICS
JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).